Proactive resistance to re-identification of genomic data

A risk assessment system configured to assess risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising:

• an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles, wherein the allele frequency information is extracted from a plurality of genetic sequences, and wherein the request frequency information comprises, for each of the plurality of genetic sequences, a count of previous requests for information about each of the plurality of alleles found within a respective genetic sequence;
• an inquirer database comprising allele request information about a plurality of inquirers, wherein the allele request information comprises information about allele frequency information previously requested by each of a plurality of inquirers;
• and
• a processor configured to receive a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer, the processor comprising:
• an allele database generator configured to update, in the allele database for each of the plurality of genetic sequences comprising the one or more alleles, the request frequency information based on the received request;
• an inquirer database generator configured to update, in the inquirer database based on the received inquirer identifier, the allele request information for the requesting inquirer;
• and
• a risk analyzer configured to:
• (i) calculate an allele risk score based on the updated allele database;
• (ii) calculate an inquirer risk score based on the updated inquirer database;
• and (ii) assess, based on the allele risk score and the inquirer risk score, a risk associated with the received request.