Accelerated pharmaceutical repurposing

A computer program product using a computing device to assist in repurposing of a pharmaceutical, the computer program product comprising:

• one or more non-transitory computer-readable storage media and program instructions stored on the one or more non-transitory computer-readable storage media, the program instructions, when executed by the computing device, cause the computing device to perform a method comprising:
• receiving by a computing device an identification of a pharmaceutical for repurposing study;
• retrieving by the computing device a pharmaceutical expression signature for the pharmaceutical based upon the identification of the pharmaceutical, the pharmaceutical expression signature indicating differential expressions of a plurality of biomolecules regulated by the pharmaceutical versus a control;
• retrieving by the computing device a plurality of disease expression signatures from a disease omics database, each disease expression signature indicating differential expressions of a plurality of biomolecules affected by a disease versus the control;
• generating by the computing device a pharmaceutical vector based upon the pharmaceutical expression signature for the pharmaceutical;
• generating by the computing device a plurality of disease vectors based upon the plurality of disease expression signatures for each disease;
• and
• generating N hypotheses correlating the pharmaceutical vector and one or more of the plurality of disease vectors, each of the N hypotheses generated when an anticorrelation exists between the pharmaceutical expression signature and one or more disease expression signatures of the plurality of disease expression signatures, each hypothesis indicating a potential repurposing for the pharmaceutical to treat the disease.

A computer system to assist in repurposing of a pharmaceutical, the computer system comprising:

• one or more computer processors;
• one or more computer-readable storage media;
• program instructions stored on the computer-readable storage media for execution by at least one of the one or more processors, the program instructions comprising:
• program instructions to receive by a computer processor an identification of a pharmaceutical for repurposing study;
• program instructions to retrieve by the computer processor a pharmaceutical expression signature for the pharmaceutical based upon the identification of the pharmaceutical, the pharmaceutical expression signature indicating differential expressions of a plurality of biomolecules regulated by the pharmaceutical versus a control;
• program instructions to retrieve by the computer processor a plurality of disease expression signatures from a disease omics database, each disease expression signature indicating differential expression of a plurality of biomolecules affected by a disease versus the control;
• program instructions to generate by the computer processor a pharmaceutical vector based upon the pharmaceutical expression signature for the pharmaceutical;
• program instructions to generate by the computer processor a plurality of disease vectors based upon the plurality of disease expression signatures for each disease;
• and
• program instructions to generate N hypotheses correlating the pharmaceutical vector and one or more of the plurality of disease vectors, each of the N hypotheses generated when an anticorrelation exists between the pharmaceutical expression signature and one or more disease expression signatures of the plurality of disease expression signatures, each hypothesis indicating a potential repurposing for the pharmaceutical to treat the disease.