Materials and methods relating to antibody targets for tuberculosis serology
OwnerMitch Magee, Joshua LaBaer +3inventors
InventorsMitch Magee, Joshua LaBaer, Lusheng Song, Garrick Wallstrom, Jacqueline Achkar
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Abstract
Embodiments of the present disclosure relate generally to detection and diagnosis of tuberculosis (TB) infections. More particularly, the present disclosure provides novel immunogenic biomarkers associated with TB infections for the diagnosis and treatment of TB. Novel TB biomarkers can enhance the diagnosis and treatment of TB by providing greater accuracy and efficiency, especially for point-of-care technologies.
Claims20
A method of diagnosing a subject as having tuberculosis (TB), the method comprising:
- performing an assay on a biological sample obtained from a subject;
- and
- measuring or detecting at least one TB biomarker or fragment thereof selected from the group consisting of Rv0054 (ssb), Rv0813c, Rv2031c, (HspX/acr), Rv0222 (echA1), Rv0948c, Rv2853 (PE_PGRS48), Rv3405c, and Rv3544c (fadE28);
- wherein the measurement or detection of the at least one TB biomarker or fragment thereof indicates that the subject has a TB infection.
A panel of biomarkers for diagnosing a subject as having tuberculosis (TB), the panel comprising:
- at least one TB biomarker or fragment thereof selected from the group consisting of Rv0054 (ssb), Rv0813c, Rv2031c, (HspX/acr), Rv0222 (echA1), Rv0948c, Rv2853 (PE_PGRS48), Rv3405c, and Rv3544c (fadE28);
- wherein the measurement or detection of the at least one TB biomarker or fragment thereof indicates that the subject has a TB infection.
Dependencies are inferred from the claim text.