Methods and devices for separation of blood components
AssigneeCanon Virginia, Inc.
InventorsNabil Mikhaiel, Lindsay Sanford, Kelly Coughenour, Jeremy Schreiber
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Abstract
The present disclosure relates to methods and devices for the separation of blood components including separation by rapid sedimentation, including in an automated fashion.
Claims37
A method of accelerating the separation of blood components from a sample, wherein the method comprises the steps of:
- (i) providing a sample in a vessel;
- (ii) mixing the sample with one or more aggregating agents to form a mixture;
- and
- (iii) incubating the mixture.
An automated method to separate previously fractionated blood components, wherein the automated method utilizes the output from visual processing algorithms as active feedback control.
A device for separating, moving and storing components of a biological sample, wherein the device comprises a piercing post to receive a sample, such that a sample vessel and the piercing post are in fluid communication, and at least a first and second arm extending perpendicular to the length of the piercing post/sample vessel complex in opposite directions, wherein each at least first and second arm has a bend at the distal end of the perpendicular segment, and a second portion of each arm which extends from the bend in a direction perpendicular to the first segment and parallel to the piercing post, such that the distal ends of the piercing post and the second portion of the arms are in opposite directions.
A method of separating blood components comprising using a controlled filter membrane that moves downward in a sample vessel at a rate equal to the anticipated sedimentation rate of the blood cells.
A method for separating plasma from other fractionated blood components, comprising the steps of:
- adding an immiscible liquid to a sample vessel containing blood components;
- tilting the vessel to a pinching position, wherein the immiscible fluid pinches off a portion of the plasma from the remainder of the blood components.
An automated device for holding and tilting one or more sample vessels to achieve an isolated portion of plasma.
Dependencies are inferred from the claim text.