Methods and kits comprising gene signatures for stratifying breast cancer patients
AssigneesIstituto Europeo di Oncologia S.r.l., Fondazione Istituto Firc Di Oncologia Molecolare (Ifom), The University of Milan
InventorsPier Paolo DI FIORE, Salvatore PECE, Manuela VECCHI, Stefano CONFALONIERI
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Abstract
The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2− breast cancer patients.
Claims33
A method for predicting a risk of breast cancer recurrence in a subject comprising steps of:
- (a) determining, in a sample the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A;
- and
- (b) calculating a risk score based upon the expression of the at least three genes.
A method for stratifying a subject into a low or high risk group of breast cancer recurrence comprising steps of:
- (a) determining, in a sample the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A;
- (b) calculating a risk score based upon the expression of the at least three genes;
- and
- (c) stratifying the subject based upon the calculated risk score.
A method for stratifying a subject into a low, intermediate, or high risk group of breast cancer recurrence comprising steps of:
- (a) determining, in a sample the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A;
- and
- (b) calculating a risk score based upon the expression of the at least three genes;
- and
- (c) stratifying the subject based upon the calculated risk score.
A method for treating a subject having a breast cancer comprising steps of:
- (a) determining, in a sample the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A;
- (b) calculating a risk score based upon the expression of the at least three genes;
- and
- (c) providing a cancer treatment to the subject.
A method for treating a subject having a breast cancer comprising steps of:
- (a) determining, in a sample the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A;
- (b) calculating a risk score based upon the expression of the at least three genes;
- and
- (c) providing a cancer treatment to the subject.
Dependencies are inferred from the claim text.