Methods for assessing risk of developing colorectal cancer
AssigneeThe University of Melbourne
InventorsMark Jenkins, Daniel Buchanan, John L. Hopper
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods and systems for assessing the risk of a human subject for developing colorectal cancer. These methods may be combined with the subjects clinical risk to improve risk analysis. Such methods may be used to assist decision making about appropriate colorectal cancer screening regimens.
Claims23
A method for assessing the risk of a human subject for developing colorectal cancer comprising:
- performing a genetic risk assessment of the subject, wherein the genetic risk assessment involves detecting, in a biological sample derived from the subject, the presence of at least 28 single nucleotide polymorphisms selected from Table 1, or a single nucleotide polymorphism in linkage disequilibrium with one or more thereof.
17-19. (canceled)
A kit comprising at least 28 sets of primers for amplifying 28 or more nucleic acids, wherein the 28 or more nucleic acids comprise a single nucleotide polymorphism selected from Table 1, or a single nucleotide polymorphism in linkage disequilibrium with one or more thereof, and/or
- a genetic array comprising at least 28 sets of probes for hybridising to 28 or more nucleic acids, wherein the 28 or more nucleic acids comprise a single nucleotide polymorphism selected from Table 1, or a single nucleotide polymorphism in linkage disequilibrium with one or more thereof.
(canceled)
A computer implemented method for assessing the risk of a human subject for developing colorectal cancer, the method operable in a computing system comprising a processor and a memory, the method comprising:
- receiving genetic risk data for the subject, wherein the genetic risk data was obtained by detecting, in a biological sample derived from the subject, the presence of at least 28 single nucleotide polymorphisms from Table 1, or a single nucleotide polymorphism in linkage disequilibrium with one or more thereof;
- processing the data to determine the risk of the human subject for developing colorectal cancer;
- outputting the risk of the human subject for developing colorectal cancer.
25-30. (canceled)
Dependencies are inferred from the claim text.