Selection of Donors for Generation of Anti-Angiogenic Vaccine Compositions Including ValloVax
AssigneeBatu Biologics, Inc.
InventorsSamuel C. Wagner, Thomas E. Ichim
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Abstract
Disclosed are methods of selecting donors for production of anti-angiogenic vaccines in order to ensure maximal elicitation of immunity. In one embodiment, the invention teaches the purposeful mismatching of major and/or minor human leukocyte antigen (HLA) between the donor and recipient. In other embodiments the invention provides a system for generating a cell bank, said cell bank comprising different donor originals that are subsequently matched with recipients for optimal immune response. In another embodiment cells are transfected to induce immunogenicity, in some embodiments, transfected with allogeneic and/or syngeneic antigens.
Claims15
A method of selecting a donor for use of said donor cells in preparation of a therapeutic vaccine inhibiting recipient angiogenesis, the method comprising:
- a) identifying antigenic determinants specific to said donor;
- b) identifying antigenic determinants specific to said recipients;
- and
- c) matching said recipient with said donor in a manner so as to allow for highest level of immunological reactivity between said donor cell and said recipient immune response.
Dependencies are inferred from the claim text.