Precision therapeutic biomarker screening for cancer

A method of identifying alternative drug therapies, the method comprising:

• receiving, at a processing unit, drug responsiveness data for a treatment drug applied to a plurality of different cell lines, each cell line differing in genomic profile from one another such that the genomic profiles for the plurality of different cell lines are mutually exclusive, the drug responsiveness data being determined from live cell testing using the treatment drug;
• identifying at least two cell lines from the plurality of different cell lines, and determining, at the processing unit, an overlap cell line cluster where one of the at least two cell lines has a high drug responsiveness value and another of the at least two cell lines has a low drug responsiveness value, and wherein the overlap cell line cluster has a drug responsiveness value for the treatment drug that is between the high drug responsiveness value and the low drug responsiveness value, wherein determining the overlap cell line cluster using a generalized finite mixture of multivariate regression (FMMR) model;
• performing, at the processing unit, an optimality algorithm process on data for a cluster of drugs to identify one or more alternative drugs exhibiting a drug responsiveness value between the high drug responsiveness value and the low drug responsiveness value;
• and
• administering to cells of one of the at least two cell lines the one or more alternative drugs.