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US 2019/0161764 A1Published application
Plant cytochrome p450
AssigneeSun Pharmaceutical Industries (Australia) Pty Ltd
InventorsThilo Hans Winzer, Tracy Carol Walker, Ian Alexander Graham
Life of this patent
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Abstract
This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode cytochrome P450 polypeptides from a Papaver somniferum cultivar; uses in the production of noscapine and identification of poppy cultivars that include genes that comprise said nucleic acid molecules.
Claims29
A vector comprising a nucleotide molecule selected from the group consisting of:
- i) the nucleotide sequence of SEQ ID NO:
- 3 or 4;
- ii) a nucleotide sequence degenerate to the nucleotide sequence defined in (i) as a result of the genetic code;
- iii) a nucleotide sequence comprising at least 90% sequence identity to the nucleotide sequence of SEQ ID NO:
- 3 or 4, wherein said nucleic acid sequence encodes a polypeptide having cytochrome P450 activity;
- iv) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 10 or 11;
- and
- v) a nucleotide sequence that encodes a polypeptide comprising at least 90% sequence identity to the protein sequence of SEQ ID NO:
- 10 or 11, wherein said polypeptide has cytochrome P450 activity.
7 more elements
A yeast, fungal, or bacterial cell transformed with a nucleic acid comprising a nucleotide molecule selected from the group consisting of:
- i) the nucleotide sequence of SEQ ID NO:
- 3 or 4;
- ii) a nucleotide sequence degenerate to the nucleotide sequence defined in (i) as a result of the genetic code;
- iii) a nucleotide sequence comprising at least 90% sequence identity to the nucleotide sequence of SEQ ID NO:
- 3 or 4, wherein said nucleic acid sequence encodes a polypeptide having cytochrome P450 activity;
- iv) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 10 or 11;
- and
- v) a nucleotide sequence that encodes a polypeptide comprising at least 90% sequence identity to the protein sequence of SEQ ID NO:
- 10 or 11, wherein said polypeptide has cytochrome P450 activity.
7 more elements
Dependencies are inferred from the claim text.