Direct reprogramming of somatic cells into myogenic cells
AssigneeThe General Hospital Corporation
InventorsKonrad HOCHEDLINGER, Ori BAR-NUR
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Abstract
Described herein are methods of generating induced muscle progenitor cells (iMPCs) and uses thereof. Embodiments further provide for methods of promoting muscle regeneration and/or repair and methods of treating a muscle disease or disorder.
Claims36
A method for generating induced muscle progenitor cells (iMPCs), the method comprising:
- treating a population of somatic cells obtained from a subject with a cyclic AMP agonist, and a TGF-β inhibitor for a time and under conditions that induce dedifferentiation of the somatic cells to a population of cells comprising iMPCs, wherein the iMPCs are proliferative, self-renewing and capable of forming skeletal muscle myotubes.
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An in vitro heterogeneous population of skeletal muscle cells comprising induced muscle progenitor cells (iMPCs).
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A method for promoting muscle regeneration and/or repair, the method comprising:
- administering a therapeutically effective amount of iMPCs to a subject in need thereof.
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A method for treating a muscle disease or disorder, the method comprising:
- administering a therapeutically effective amount of iMPCs to a subject in need thereof.
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Dependencies are inferred from the claim text.