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US 2019/0161550 A1Published application
Antibodies against mac-1
AssigneesAlbert-Ludwigs-Universität Freiburg, Baker IDI Heart and Diabetes Institute Holdings Limited
InventorsAndreas ZIRLIK, Dennis WOLF, Karlheinz PETER
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Abstract
The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.
Claims19
An isolated monoclonal antibody or an antigen-binding portion thereof which
- a) binds to Mac-1,
- b) specifically inhibits the interaction of CD40L with activated Mac-1 and
- c) does not induce integrin outside-in signaling.
An isolated monoclonal antibody or antigen-binding portion thereof wherein it is selected from the group comprising Fab fragments, single chain antibodies, diabodies and/or nanobodies.
Dependencies are inferred from the claim text.