SP35 Antibodies And Uses Thereof

An antibody or antigen-binding fragment thereof that specifically binds LINGO-1, wherein the antibody or antigen-binding fragment thereof comprises

• a heavy chain variable region (VH) comprising complementarity determining regions (CDRs), CDRH1, CDRH2, and CDRH3 consisting of the amino acid sequences set forth in SEQ ID NO:410, SEQ ID NO:411, and SEQ ID NO:412, respectively;
• and
• a light chain variable region (VL) comprising CDRL1, CDRL2, and CDRL3 consisting of the amino acid sequences set forth in SEQ ID NO:413, SEQ ID NO:414, and SEQ ID NO:415, respectively.

One or more nucleic acid molecules encoding an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein the VH and VL comprise CDR1, CDR2, and CDR3 regions,

• wherein the CDRH1, CDRH2, and CDRH3 regions of the VH comprise the amino acid sequences of SEQ ID NO:410, SEQ ID NO:411, and SEQ ID NO:412, respectively, and
• the CDRL1, CDRL2, and CDRL3 regions of the VL comprise the amino acid sequences of SEQ ID NO:413, SEQ ID NO:414, and SEQ ID NO:415, respectively, and
• wherein an antibody comprising said VH and VL, or an antigen-binding fragment thereof, can specifically bind to LINGO-1.

An antibody or antigen-binding fragment thereof that specifically binds LINGO-1, wherein the antibody or antigen-binding fragment thereof comprises

• a heavy chain variable region (VH) comprising the amino acid sequence set forth in SEQ ID NO:432;
• and
• a light chain variable region (VL) comprising the amino acid sequences set forth in SEQ ID NO:431.