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US 2019/0161544 A1Published application
Anti-human interleukin-17a monoclonal antibody, and preparation method and use thereof
AssigneeSunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
InventorsChenghai ZHANG, Lingqiao ZHU, Jinlin GUO, Jie ZHAO, Honghai GAO, Lin MA, Wei DANG, Yan YANG
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Abstract
An anti-human IL-17A monoclonal antibody, the preparation method, and the use thereof are provided. The anti-human IL-17A monoclonal antibody can specifically bind to human IL-17A and has a good effect for inhibiting the secretion of inflammatory cytokines, such as IL-6 and the like by means of various cell lines induced by IL-17A, and can be used for preparing drugs for treating diseases involving immune-medicated inflammatory responses.
Claims15
An anti-human IL-17A monoclonal antibody, comprising:
- (1) a heavy chain complementarity determining region CDR1, CDR2, CDR3, wherein the CDR1 has the amino acid sequence as shown in SEQ ID NO:
- 5, the CDR2 has the amino acid sequence as shown in SEQ ID NO:
- 6, and the CDR3 has the amino acid sequence as shown in SEQ ID NO:
- 7;
- and
- (2) a light chain complementarity determining region CDR1′, CDR2′, CDR3′, wherein the CDR1′ has the amino acid sequence as shown in SEQ ID NO:
- 8, the CDR2′ has the amino acid sequence as shown in SEQ ID NO:
- 9, and the CDR3′ has the amino acid sequence as shown in SEQ ID NO:
- 10.
6 more elements
Dependencies are inferred from the claim text.