Combination therapy
AssigneeEli Lilly and Company
InventorsMansuo Lu Hayashi, Michael Carl Irizarry
Life of this patent
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Abstract
A method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-N3pGlu Abeta antibody, an anti-Abeta antibody, or an antibody fragment that binds Amyloid beta and is covalently attached to a polyethylene glycol molecule, in combination with an effective amount of an anti-Tau antibody.
Claims21
A method of treating a patient having a disease characterized by deposition of amyloid β (Aβ), comprising administering to a patient in need of such treatment an effective amount of an anti-N3pGlu Abeta antibody, in combination with an effective amount of an anti-Tau antibody, wherein the anti-Tau antibody comprises a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3 and the HCVR comprises CDRs HCDR1, HCDR2, and HCDR3, wherein the amino acid sequence of LCDR1 is given by SEQ ID NO.69, the amino acid sequence of LCDR2 is given by SEQ ID NO.70, the amino acid sequence of LCDR3 is given by SEQ ID NO.71, the amino acid sequence of HCDR1 is given by SEQ ID NO. 72, the amino acid sequence of HCDR2 is given by SEQ ID NO.73, and the amino acid sequence of HCDR3 is given by SEQ ID NO.75.
A pharmaceutical composition, comprising an anti-N3pGlu Abeta antibody, with one or more pharmaceutically acceptable carriers, diluents, or excipients, in combination with a pharmaceutical composition of anti-Tau antibody, with one or more pharmaceutically acceptable carriers, diluents, or excipients, wherein the anti-Tau antibody comprises a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3 and the HCVR comprises CDRs HCDR1, HCDR2, and HCDR3, wherein the amino acid sequence of LCDR1 is given by SEQ ID NO.69, the amino acid sequence of LCDR2 is given by SEQ ID NO.70, the amino acid sequence of LCDR3 is given by SEQ ID NO.71, the amino acid sequence of HCDR1 is given by SEQ ID NO. 72, the amino acid sequence of HCDR2 is given by SEQ ID NO.73, and the amino acid sequence of HCDR3 is given by SEQ ID NO.75.
19-72. (canceled)
Dependencies are inferred from the claim text.