Cell
AssigneesUCL Business PLC, Autolus Limited
InventorsMartin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
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Abstract
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
Claims8
1-45. (canceled)
A chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a VH domain having the sequence shown as SEQ ID NO 24, and a VL domain having the sequence shown as SEQ ID No. 26 or SEQ ID No. 40.
A CAR according to claim 22, wherein the CD19 binding domain comprises the sequence shown as SEQ ID No. 22 or SEQ ID No. 39.
A cell comprising a CAR according to claim 1.
A nucleic acid sequence encoding a CAR according to claim 1.
A vector which comprises a nucleic acid sequence according to claim 4.
A pharmaceutical composition comprising a plurality of cells according to claim 3.
Dependencies are inferred from the claim text.