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US 2019/0161528 A1Published application
Claudin-6 peptides
OwnerAlex POWLESLAND, Mei SUNinventors
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Abstract
The present invention relates to novel peptides derived from Claudin-6 (CLDN6), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
Claims16
A polypeptide comprising, consisting essentially of or consisting of
- (i) the amino acid sequence SLLALPQDLQA (SEQ ID NO:
- 1):
- (ii) the amino acid sequence VLTSGIVFV (SEQ ID NO:
- 2)
- (iii) the amino acid sequence TLIPVCWTA (SEQ ID NO:
- 3)
- (iv) the amino acid sequence AISRGPSEYPTKNYV (SEQ ID NO:
- 4)
- (v) the amino acid sequence GLLLLGGGL (SEQ ID NO:
- 5)
- (vi) the amino acid sequence of SEQ ID NOs:
- 1-5 with the exception of 1, 2 or 3 amino acid substitutions, and/or 1, 2 or 3 amino acid insertions, and/or 1, 2 or 3 amino acid deletions, wherein the polypeptide forms a complex with a Major Histocompatibility Complex (MHC) molecule.
9 more elements
A complex of the polypeptide of any preceding claim and a Major Histocompatibility Complex (MHC) molecule.
Dependencies are inferred from the claim text.