Pharmaceutical composition and the use therof in the treatment of autoimmune diseases
AssigneeSingapore Health Services Pte Ltd
InventorSalvatore ALBANI
Life of this patent
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Abstract
The present invention relates to compounds comprising formula I: Amino Acid Sequence-(L)n-DMARD wherein the amino acid sequence comprises QKRAAYDQYGHAAFE-NH2 (SEQ ID NO: 1), DMARD is a disease modifying antirheumatic agent, L is a linker unit; —is a covalent bond and n is 0 or 1 and methods of using the compound for treatment of autoimmune diseases. In a preferred embodiment the DMARD is selected from Chloroquine and Hydroxychloroquine.
Claims27
A method of treating an autoimmune related disease in a subject in need, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound having the following general formula I:
- Amino Acid Sequence-(L)n-DMARD
- wherein the amino acid sequence comprises QKRAAYDQYGHAAFE-NH2 (SEQ ID NO:
- 1), DMARD is a disease modifying antirheumatic agent, L is a linker unit,—is a covalent bond and n is 0 or 1.
3-12. (canceled)
(canceled)
18-20. (canceled)
22-23. (canceled)
A compound having formula I:
- Amino Acid Sequence-(L)n-DMARD
- wherein the amino acid sequence comprises QKRAAYDQYGHAAFE-NH2 (SEQ ID NO:
- 1), DMARD is a disease modifying antirheumatic agent, L is a linker unit,—is a covalent bond and n is 0 or 1.
26-28. (canceled)
33-35. (canceled)
38-79. (canceled)
Dependencies are inferred from the claim text.