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US 2019/0161516 A1Published application
Proteasome inhibitors
AssigneeUniversity of Kentucky Research Foundation
InventorKyung Bo Kim
Life of this patent
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Abstract
Unique epoxyketone compounds useful for inhibiting a proteasome in a cell, pharmaceutical compositions and methods of their use are provided herein.
Claims12
A compound, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, of the formula:
- wherein R1, R2, R3 and R8 are independently selected from
- R4 is selected from
- R5 is selected from H or CH3;
- R6 is selected from
- and R7 is selected from
2 more elements
A compound, or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof selected from
Dependencies are inferred from the claim text.