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US 2019/0161492 A1Published application
Process for preparing oxycodone compositions
AssigneesPurdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P., Rhodes Technologies
InventorsRobert CHAPMAN, Lonn S. RIDER, Qi HONG, Donald KYLE, Robert KUPPER
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Abstract
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Claims27
1-70. (canceled)
A process of purifying oxycodone free base or oxycodone HCl that contains 8α,14-dihydroxy-7,8-dihydrocodeinone or HCl salt thereof, said process comprising:
- (i) reducing the amount of 8α,14-dihydroxy-7,8-dihydrocodeinone or HCl salt thereof in the oxycodone free base or oxycodone HCl;
- (ii) dissolving the resultant oxycodone free base or oxycodone HCl from step (i) in a suitable recrystallization solvent;
- (iii) cooling the recrystallization solvent to precipitate purified oxycodone free base or oxycodone HCl;
- and
- (iv) recovering the purified oxycodone free base or oxycodone HCl.
2 more elements
Dependencies are inferred from the claim text.