Novel 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo Derivatives and Pharmaceutical Composition Comprising the Same

A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:

• in Chemical Formula 1,
• A is a benzene ring, or a 6-membered heteroaromatic ring containing one to three nitrogen atoms,
• R1 is C1-10 alkyl;
• C6-10 aryl;
• C1-10 heteroaryl containing one to four heteroatoms each independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• or C3-10 heterocycloalkyl containing one to four heteroatoms each independently selected from the group consisting of nitrogen, oxygen, and sulfur,
• wherein R1 is unsubstituted or substituted with one to three substituents each independently selected from the group consisting of halogen, cyano, hydroxy, amino, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy,
• R2 and R3 are each independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or C1-4 haloalkyl,
• L1 is a bond, O, S, SO2, NH, N(C1-4 alkyl), NHCO, N(C1-4 alkyl)CO, NHCONH, N(C1-4 alkyl)CONH, NHCON(C1-4 alkyl), N(C1-4 alkyl)CON(C1-4 alkyl), CONH, CON(C1-4 alkyl), SO2NH, or SO2N(C1-4 akyl),
• L2 is methylene, or ethylene,
• one of X, and X2 is CH2, and the other is N—CO—R′,
• wherein R′ is C1-4 alkyl;
• C2-4 alkenyl;
• or C2-4 alkynyl, each of which is unsubstituted or substituted by one to three substituents each independently selected from the group consisting of halogen, cyano, hydroxy, amino, NH(C1-4 alkyl), N(C1-4 alkyl)2, C3-10 cycloalkyl, and C3-10 heterocycloalkyl containing one or two heteroatoms each independently selected from the group consisting of nitrogen, and oxygen, and
• each of a and b independently represents an integer of 0 to 4.