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US 2019/0161484 A1Published application
Solid forms of a compound for modulating kinases
AssigneePlexxikon Inc.
InventorsPrabha N. Ibrahim, Hamid Rezaei, Marika Nespi, Ben Powell, Rashmin Patel
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Abstract
Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl]pyrrolo[3,2-b]pyridin-3-yl)benzoic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.
Claims21
A free acid amorphous form of Compound I:
- characterized by an X-ray powder diffractogram as substantially shown in FIG. 18.
A crystalline form of Compound I:
- characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 17.1, 19.4, and 23.5°2θ as determined on a diffractometer using Cu-Kα radiation.
A crystalline form of Compound I:
- characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 16.8, 17.4, and 21.1°2θ as determined on a diffractometer using Cu-Kα radiation.
A crystalline form of Compound I:
- characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 13.7, 14.6, and 22.6°2θ as determined on a diffractometer using Cu-Kα radiation.
A crystalline form of Compound I:
- characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 3.5, 18.0, and 19.1°2θ as determined on a diffractometer using Cu-Kα radiation.
Dependencies are inferred from the claim text.