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US 2019/0161480 A1Published application
Chemical Compounds
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsSebastien Andre CAMPOS, Samuel Edward DALTON, Vipulkumar Kantibhai PATEL
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Abstract
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
Claims12
A compound of formula (I)
- wherein
- R1 is hydrogen, C1-6alkyl or phenyl, wherein the C1-6alkyl is optionally substituted by —CF3 and the phenyl is optionally substituted by one or two substituents independently selected from C1-6alkyl, C1-6alkoxy, halogen, —CN, —CF3, —CO2R2, —CO2NHR3, —NR4R5, —NO2 and —SF5,
- R2 to R5 are each independently selected from hydrogen and C1-6alkyl,
- or a salt thereof.
1 more element
A compound which is:
- methyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 5-(4-(5((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinic acid;
- 2-nitrophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 4-nitrophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 2-(trifluoromethyl)phenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl) oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 4-(trifluoromethyl)phenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 4-fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- phenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 2,4-dimethylphenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 4-methoxyphenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- 2,2,2-trifluoroethyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate,
- or a salt thereof.
9 more elements
7-9. (canceled)
Dependencies are inferred from the claim text.