Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine

A compound represented by formula (I) or a stereoisomer, tautomer thereof or a pharmaceutically acceptable salt thereof:

• wherein:
• each of R1 is independently selected from alkyl, halogen, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 or —NR7C(O)R8, wherein the alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more substituents selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
• R2 is selected from:
• —NR4C(O)CR5═CHR6 or —NR4C(O)C≡CR5;
• R3 is a spiroheterocyclyl, wherein the spiroheterocyclyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
• or
• R3 is a monocyclic heterocyclyl, wherein the monocyclic heterocyclyl is further substituted by one or more substituents selected from the group consisting of cycloalkyl and —NR7R8;
• each of R4 is independently selected from hydrogen or alkyl, wherein the alkyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
• R5 and R6 are each independently selected from hydrogen, alkyl or halogen, wherein the alkyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
• R7, R8 and R9 are each independently selected from hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR10R11, —C(O)NR10R11, —C(O)R12, —C(O)OR and —NR10C(O)R11;
• alternatively, R7 and R8 together with the N atom to which they are attached form a 4 to 8 membered heterocyclyl, wherein the 4 to 8 membered heterocyclic ring contains one or more N, O, S(O)n atoms, and the 4 to 8 membered heterocyclic ring is further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, ═O, —NR10R11, —C(O)NR10R11, —C(O)R12, —C(O)OR12 and —NR10C(O)R11;
• R10, R11 and R12 are each independently selected from hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl are optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxylic acid or carboxylate;
• m is 1, 2, 3 or 4;
• and
• n is 0, 1, or 2.