Method for producing indole compound
AssigneeJapan Tobacco Inc.
InventorsTeruhiko INOUE, Koji MATSUMURA, Shinichi KIKUCHI
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Abstract
The present invention aims to provide a new method for producing an indole compound or a salt thereof, which has an ITK inhibitory action, and is useful for the prophylaxis or treatment of inflammatory disease. The present invention is a method for producing N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-(2S)-2-(morpholin-4-yl)propanamide, which comprises a step of reacting
Claims16
A method of producing a compound of the formula [I]
- which comprises a step of removing the protecting group from a compound of the formula [III]
- to give a compound of the formula [I].
A method of producing a compound of the formula [II]
- which comprises a step of treating a compound of the formula [I]
- with hydrogen chloride to give a compound of the formula [II].
A method of producing a compound of the formula [II]
- which comprises a step of removing the protecting group from a compound of the formula [III]
- to give a compound of the formula [I], and
- a step of treating a compound of the formula [I]
- with hydrogen chloride to give a compound of the formula [II].
A method of producing a compound of the formula [XI]
- wherein R2 is hydrogen, C1-6 alkyl or C1-6 alkoxy,
- which comprises a step of subjecting a compound of the formula [XII]
- wherein R2 is as defined above,
- to methylation.
A compound of the formula [V]
A compound of the formula [III]
A compound of the formula [VI]
- wherein R1 and R2 are each independently hydrogen, C1-6 alkyl or C1-6 alkoxy.
A compound of the formula [VII]
- wherein R1 is hydrogen, C1-6 alkyl or C1-6 alkoxy.
A compound of the formula [VIII]
- wherein R1 is hydrogen, C1-6 alkyl or C1-6 alkoxy.
A compound of the formula [XI]
- wherein R2 is hydrogen, C1-6 alkyl or C1-6 alkoxy.
Dependencies are inferred from the claim text.