Chemical compound of isocitrate dehydrogenase inhibitor, and application thereof

A compound represented by formula (I) or an isomer, a pharmaceutically acceptable salt, crystal, solvate or prodrug thereof,

• wherein
• R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, cycloalkyl, heterocyclyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, amino, alkylamino, alkylacylamino, alkylacyl, aminoacyl, alkylaminoacyl, carboxyl, nitro and cyano, wherein the halogen, hydroxyl, alkyl, cycloalkyl, heterocyclyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, amino, alkylamino, alkylacylamino, alkylacyl, aminoacyl, alkylaminoacyl, carboxyl, nitro and cyano are optionally substituted with one or more groups selected from the group consisting of halogen, hydroxyl, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, hydroxyalkoxy, nitro, carboxyl, cyano, amino, monoalkylamino, dialkylamino, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• X is selected from the group consisting of N(R3), O, S, and C(R4), wherein R3 is selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl and aminomercaptoalkyl, or R3 and Y together with the nitrogen atom to which they are attached form optionally substituted heterocyclyl, and R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, hydroxyl, hydroxyalkyl, halogen, oxo group, alkoxy, carboxyl, cyano, amino and aminoalkyl, or R4 and Y together with the carbon atom to which they are attached form optionally substituted carbocyclyl or heterocyclyl, wherein the alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, aminomercaptoalkyl, alkenyl, hydroxyl, halogen, oxo group, alkoxy, carboxyl, cyano and amino are optionally substituted with one or more groups selected from the group consisting of halogen, hydroxyl, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, hydroxyalkoxy, nitro, carboxyl, cyano, amino, monoalkylamino, dialkylamino, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• Y is selected from the group consisting of optionally substituted alkyl, O(R5), N(R6R7), cycloalkyl, heterocyclyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, alkylamino, alkylacylamino, alkylacyl, aminoacyl and alkylaminoacyl, wherein R5, R6 and R7 are each independently selected from the group consisting of optionally substituted alkyl, cycloalkyl and heterocyclyl, or R6 and R7 together with the nitrogen atom to which they are attached form heterocyclyl, and
• when X is N(R3) and R3 is hydrogen, Y is selected from the group consisting of optionally substituted O(R5) and N(R6R7), and the dotted line between X and Y represents a single bond;
• when X is N(R3) and R3 is selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl and aminomercaptoalkyl, Y is selected from the group consisting of optionally substituted alkyl, O(R5) and N(R6R7), and the dotted line between X and Y represents a single bond, or R3 and Y together with the nitrogen atom to which they are attached form optionally substituted heterocyclyl;
• when X is selected from the group consisting of O and S, Y is selected from the group consisting of optionally substituted alkyl, cycloalkyl, heterocyclyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, alkylamino, alkylacylamino, alkylacyl, aminoacyl and alkylaminoacyl, and the dotted line between X and Y represents a single bond;
• and
• when X is C(R4), Y is selected from the group consisting of optionally substituted alkyl, cycloalkyl, heterocyclyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, alkylamino, alkylacylamino, alkylacyl, aminoacyl and alkylaminoacyl, and the dotted line between X and Y represents a single bond, a double bond or a triple bond, or R4 and Y together with the carbon atom to which they are attached form optionally substituted carbocyclyl or heterocyclyl.