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US 2019/0161459 A1Published application
Polyfunctional compounds, methods for preparing same and uses thereof
AssigneeUniversite Du Mans
InventorsPhilippe BERTUS, Laurent FONTAINE, Morwenna PEARSON-LONG, Fabien BOEDA, Julien CAILLE, Valentin GAIGNET
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Abstract
Disclosed are polyfunctional compounds of formula: as well as methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
Claims20
Compound of general formula (I)
- in which:
- Y is a reactive functional group selected from the group comprising:
- (i) an N3 group,
- (ii) a (C2-C10) alkenyl group,
- (iii) a (C2-C10) alkynyl group,
- (iv) a (C3-C10) cycloalkenyl group, in particular a (C3-C7) cycloalkenyl group,
- (v) a (C7-C10) cycloalkynyl group, more particularly a cyclooctynyl group or a cyclooctyne derivative,
- (vi) an anthracenyl group,
- (vii) a furanyl group,
- (viii) a maleimidyl group,
- (ix) a tetrazinyl group,
- (x) a group capable of a cycloaddition,
- A is a group selected from:
- (a) a linear or branched —(CH2)m— alkylene chain, m being an integer from 0 to 20,
- (b) an aromatic group of 6 to 14 carbon atoms,
- (c) a (C3-C18) cycloalkyl group,
- (d) a heterocyclic group comprising from 3 to 18 members,
- R1 is a (C2-C10) alkenyl group or a (C2-C10) alkynyl group
- n is an integer from 0 to 3.
16 more elements
Dependencies are inferred from the claim text.