Novel derivatives of curcuminoids and use thereof as an anticancer agent

Compound having the following formula:

• wherein Ra, Rb, Ra′ and Rb′ independently are H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 fluoroalkoxy, amino, amino(C1-C6 alkyl), nitro, heteroaryl, OH, —OC(═O)Rd, —OC(═O)ORd, or —OC(═O)N(Rd)2, wherein Rd is H, C1-C6 alkyl, or C1-C9 alkylol;
• Rc is H, C1-C6 alkyl, C3-C6 unsaturated alkyl with a double or triple bond, C1-C9 alkylol, C7-C12 arylalkyl, or —CH2-OC(═O)Rd;
• and Re and Re′ independently are H, C1-C6 alkyl, C1-C6 alkoxy;
• wherein at least one of Ra, Rb, Ra′, and Rb′ is —OC(═O)Rd, and Rd is a C3-C9 branched alkylol;
• wherein said compound is interconvertible between keto and enol forms, when Rc is H, or a pharmaceutically acceptable salt thereof.