Methods and devices for treating hpv-associated lesions using nanosecond pulsed electric fields
AssigneePulse Biosciences, Inc.
InventorsRichard Lee Nuccitelli, Darrin Robert Uecker
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Abstract
In one aspect, methods of treating human papillomavirus (HPV)-associated growths are provided in which nano-pulse stimulation is applied at the site of a cancer. In another aspect, devices and computer systems for delivering nano-pulse stimulation for the treatment of HPV-associated growths are provided.
Claims30
A method of treating a subject having a human papillomavirus (HPV)-associated growth, the method comprising applying a treatment of sub-microsecond pulses of an electric field with an intensity of 1 kV/cm or greater to the subject at a site of the HPV-associated growth, wherein the pulses are applied at a rate of energy deposition of up to about 14 watts/cc;
- thereby treating the subject having the HPV-associated growth.
A method of inhibiting the recurrence of an HPV-associated growth or a metastasis of a cancer in a subject, the method comprising applying a treatment of sub-microsecond pulses of an electric field with an intensity of 1 kV/cm or greater to a site of the HPV-associated growth or metastasis in or on the subject, wherein the treatment comprises applying the pulses at a rate of energy deposition that is less than 14 watts/cc.
A device for delivering treatment of sub-microsecond pulses of an electric field, comprising:
- a pulse generator configured to generate electric pulses;
- an electrode assembly configured to deliver the electric pulses to a site of an abnormal growth in or on a subject, wherein the pulse generator and the electrode assembly are configured to apply a plurality of sub-microsecond pulses of an electric field with an intensity of 1 kV/cm or greater to the site of the abnormal growth;
- and
- a processor operatively connected with a machine-readable non-transitory medium, the medium embodying information indicative of instructions for causing the processor to perform operations comprising:
- controlling the pulse generator to generate a number of pulses in a treatment session, each pulse having a pulse duration and a pulse amplitude calculated to deliver the pulses at a rate of energy deposition of up to 14 watts/cc.
A machine-readable non-transitory medium embodying information indicative of instructions for causing a device comprising a pulse generator to perform operations for delivering treatment of sub-microsecond pulses of an electric field, the operations comprising:
- controlling the pulse generator to generate a number of pulses in a treatment session, each pulse having a pulse duration and a pulse amplitude calculated to deliver the pulses at a rate of energy deposition of up to 14 watts/cc to a site of an abnormal growth in or on a subject through an electrode assembly coupled to the pulse generator.
A computer system for controlling a high voltage pulse generator, the system comprising:
- a processor;
- and
- a memory operatively coupled with the processor, the processor executing instructions from the memory comprising:
- program code for controlling a pulse generator to generate a number of pulses in a treatment session, each pulse having a pulse duration and a pulse amplitude calculated to deliver the pulses at a rate of energy deposition of up to 14 watts/cc to a site of an abnormal growth in or on a subject through an electrode assembly coupled to the pulse generator.
Dependencies are inferred from the claim text.