Apparatus and method for generating and concentrating fine particle aerosols
AssigneeKaer Biotherapeutics Corporation
InventorDonovan B Yeates
Life of this patent
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Abstract
A system and a method for generating a respirable dry powder aerosol from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow. A liquid aerosol generating nozzle generates from the liquid solution or liquid suspension a liquid aerosol that is diluted by dilution gas and dried in a cylindrical evaporation chamber to generate a dry powder aerosol. The system and method include heliox as a gas, specifically dilution gas, for enhancing the drying process in the cylindrical evaporation chamber, but also as a nozzle gas for enhancing generating the liquid aerosol from the liquid solution or liquid suspension.
Claims20
An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, comprising:
- a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox;
- and
- a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow and a first intermediate dry powder aerosol particle concentration.
A method for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, comprising:
- feeding liquid solution or liquid suspension and nozzle heliox into a liquid aerosol generating nozzle;
- outputting from the liquid aerosol generating nozzle a liquid aerosol suspended in the nozzle heliox into a cylindrical evaporation chamber;
- feeding dilution gas into the cylindrical evaporation chamber;
- and
- outputting from the cylindrical evaporation chamber a first intermediate dry powder aerosol having fine dry powder particles that allow respirable particles containing a medically active agent and are suspended in gas at a first intermediate dry powder aerosol volume flow and a first intermediate dry powder aerosol particle concentration.
Dependencies are inferred from the claim text.