Bioabsorbable dermal regeneration matrix and methods of making and using same
AssigneeDuke University
InventorsHoward Levinson, Elizabeth R. Lorden, David A. Brown
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Abstract
Disclosed herein are wound healing products and methods of making and using the same. The wound healing product comprises a porous scaffold and collagen bound thereon. The scaffold may comprise a poly(L-lactide-co-ε-caprolactone) polymer (PLCL) substrate. In some embodiments, the PLCL substrate comprises a mixture of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PLC) and wherein the PLA and PLC are present in a ratio of about 60:40 to about 40:60. In some embodiments, the collagen is collagen I or collagen III. The scaffold may also have a thickness of at least 0.2 mm.
Claims46
A wound healing product comprising a porous scaffold and collagen bound thereon,
- wherein the scaffold comprises a poly(L-lactide-co-ε-caprolactone) polymer (PLCL) substrate having a porosity of between 60% and 95% and a thickness of at least 0.2 mm,
- wherein the scaffold has a mean pore diameter of between 50 microns and 250 microns, and
- wherein the scaffold has a pore interconnectivity of greater than 80%.
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A method for preparing a porous scaffold or a wound healing product, the method comprising:
- (a) evaporating a polymer slurry solvent from a polymer slurry within a mold to prepare a polymer substrate surrounding a porogen, wherein the polymer slurry comprises the polymer slurry solvent, the porogen insoluble in the polymer slurry solvent, a solvent-soluble polymer, and a surfactant;
- (b) dissolving the porogen with a porogen solvent to prepare a polymer substrate having a plurality of pores;
- (c) etching the polymer substrate having a plurality of pores with an oxygen plasma to prepare an etched polymer substrate;
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- (d) reacting collagen with the etched polymer substrate to prepare the wound healing product.
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Dependencies are inferred from the claim text.