Compositions comprising a polysaccharide matrix for the controlled release of active ingredients
AssigneeJointherapeutics S.R.L.
InventorsMargherita Morpurgo, Giulio Bianchini, Lanfranco Callegaro
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Abstract
The present application describes compositions that can be used for the controlled release of pharmacological active ingredients from a viscoelastic aqueous polysaccharide matrix, and their potential use in the treatment of different stages of musculoskeletal diseases. The combination of drug release modulation and the viscoelastic nature of the composition makes possible the use thereof in the treatment of acute and chronic phases of musculoskeletal diseases characterized by an inflammatory state, and where a therapeutic effect and a viscosupplemental contribution are required.
Claims17
Compositions comprising a clathrate consisting in a cyclodextrin and an active ingredient, wherein the cyclodextrin and active ingredient clathrate is homogeneously dispersed in a polysaccharide polymer matrix in aqueous solution formed by hyaluronic acid and/or salts thereof and an oligosaccharide derivative of chitosan with lactose, said derivative being obtained by reductive amination reaction of chitosan D-glucosamine, and having a degree of substitution of the amine functional group with lactose of at least 40%.
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Dependencies are inferred from the claim text.