Back to results
US 2019/0160171 A1Published application
Biodegradable drug delivery for hydrophobic compositions
AssigneeMedincell
InventorsGeorges GAUDRIAULT, Christophe ROBERGE
Life of this patent
Estimating the term…
Abstract
A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as at least one pharmaceutically active principle or hydrophobic active principle such as medroxyprogesterone acetate, levonorgestrel, cyclosporine, progesterone or bupivacaine is disclosed.
Claims6
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- Av-Bw-Ax
- wherein A is a polyester and B is polyethylene glycol, wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- and
- (b) a biodegradable diblock copolymer having the formula:
- Cy-Az
- wherein A is a polyester and C is an end-capped polyethylene glycol wherein y and z are the number of repeat units y ranging from 3 to 45 and z ranging from 7 to 327, wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable CA diblock copolymer of (b) is 1:3 to 1:8 or 1:1 to 1:19 or 3:2 to 1:19 in said biodegradable drug composition;
- and (c) at least one pharmaceutically hydrophobic active principle.
5 more elements
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- Av-Bw-Ax
- wherein A is a polyester and B is polyethylene glycol, wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x, v and x being ester repeat units and w being ethylene oxide repeat units and v=x or v≠x;
- and
- (b) a biodegradable diblock copolymer having the formula:
- Cy-Az
- wherein A is a polyester and C is an end-capped polyethylene glycol wherein y and z are the number of repeat units y ranging from 3 to 45 and z ranging from 7 to 327, y being the number of ethylene oxide repeat units and z the number of ester repeat units, wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable CA diblock copolymer of (b) is 1:3 to 1:8 or 1:1 to 1:19 or 3:2 to 1:19 in said biodegradable drug composition;
- and (c) at least one pharmaceutically hydrophobic active principle.
5 more elements
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- PLAv-PEGw-PLAx
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- and
- (b) a biodegradable diblock copolymer having the formula:
- PEGy-PLAz
- wherein y and z are the number of repeat units y ranging from 3 to 45 and z ranging from 7 to 327, wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 1:3 to 1:8 or 1:1 to 1:19 or 3:2 to 1:19 in said biodegradable drug composition and wherein the PEG in the diblock is end-capped;
- and (c) at least one pharmaceutically hydrophobic active principle
5 more elements
Dependencies are inferred from the claim text.