Combination therapy using inhibitors of human growth and differentiation factor 15 (gdf-15) and immune checkpoint blockers
AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsJörg WISCHHUSEN, Markus HAAKE, Reinhard DUMMER, Matthias MEHLING, Tina SCHÄFER, Martina SELLE
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Abstract
The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
Claims21
1-65. (canceled)
A method of increasing the percentage of CD8+ T-cells in a solid cancer in a patient in need thereof, the method comprising administering to the patient a combination of an hGDF-15 inhibitor and an immune checkpoint blocker.
A method of treating a solid cancer in a patient in need thereof, the method comprising administering to the patient a combination of an hGDF-15 inhibitor and an immune checkpoint blocker.
Dependencies are inferred from the claim text.