Back to results
US 2019/0160167 A1Published application
Pseudo-viral particles and uses of same
AssigneeAngany Inc.
InventorsVéronique GOMORD, Louis-Philippe VEZINA, Loïc FAYE, Virginie CATALA, Anne-Catherine FITCHETTE
Life of this patent
Estimating the term…
Abstract
The present invention relates to a type I or II transmembrane fusion protein comprising, successively: a) optionally, a signal peptide; b) a protein or a peptide of interest; c) a coiled-coil domain; and d) a domain for anchoring in the plasma membrane, consisting of a transmembrane segment and a cytosolic segment. It also relates to the virus-like particles obtained with this fusion protein.
Claims12
A virus-like particle comprising:
- an envelope consisting of a plasma membrane of which at least one portion is typical of lipid rafts;
- and
- at least one type I or II transmembrane fusion protein anchored in said membrane, said fusion protein comprising the following fragments, successively:
- b) a protein or a peptide of interest;
- c) a coiled-coil domain or oligomerization sequence, which does not originate from a virus;
- and
- d) a domain for anchoring in the plasma membrane, consisting of a transmembrane segment and a cytosolic segment, preferably a domain for anchoring in a plasma membrane of which at least one portion is typical of lipid rafts, fragments b) and c) being exposed at the surface of the virus-like particle.
4 more elements
A type I or type II transmembrane fusion protein comprising the following fragments, successively:
- a) optionally, a signal peptide;
- b) a protein or a peptide of interest;
- c) a coiled-coil domain or oligomerization sequence, which does not originate from a virus;
- and
- d) a domain for anchoring in the plasma membrane, consisting of a transmembrane segment and a cytosolic segment, preferably a domain for anchoring in a plasma membrane of which at least one portion is typical of lipid rafts.
2 more elements
Dependencies are inferred from the claim text.