Preparation of flagellin vaccine adjuvant-based vaccine to induce production of antibody recognizing conformation of antigens, and application thereof
AssigneeIndustry Foundation of Chonnam National University
InventorsJoon Haeng RHEE, Shee Eun LEE, Kwangjoon JEONG, Sang Chul PARK, Wenzhi TAN
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Abstract
The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.
Claims16
1-23. (canceled)
A composition containing a recombinant protein comprising:
- (a) a repeated domain (RD) of tau (τ) protein;
- and
- (b) FlaB protein derived from Vibrio vulnificus.
A method for treatment of a neurodegenerative disease, the method comprising administering the composition containing a recombinant protein comprising:
- (a) a repeated domain (RD) of tau (τ) protein;
- and
- (b) FlaB protein derived from Vibrio vulnificus,
- to a subject.
A method for providing information necessary for diagnosis of a neurodegenerative disease, the method comprising measuring a degree of production of an antibody produced by administering the composition containing a recombinant protein comprising:
- (a) a repeated domain (RD) of tau (τ) protein;
- and
- (b) FlaB protein derived from Vibrio vulnificus,
- to a subject.
A codon-optimized nucleotide of SEQ ID NO:
- 5 coding a repeated domain (RD) of tau (τ) protein.
Dependencies are inferred from the claim text.