Multivalent Biologic Constructs for Inducing A Therapeutic Modulation of Cellular Response and Uses Thereof

Abstract

The presently-disclosed subject matter includes a multivalent biological construct that comprises a scaffold of anisometric dimensions, comprises a biodegradable hydrophobic core coated with a hydrophilic coat of fluidic material, and pluralities of bioactive molecules tethered to said scaffold. The multivalent biologic construct interacts simultaneously with multiple corresponding binding sites, increasing the functional affinity to induce an augmented therapeutic action in the form of stimulation, activation, competitive inhibition, consumptive inhibition or modulation of a biological system. Embodiments of the presently-disclosed subject matter include methods for preparation of the present construct as well as methods for using the present constructs to overcome cellular resistance, as thrombolytics, as competitive inhibitors, as consumptive inhibitors, as vaccines and as immunomodulators to treat a subject in need thereof.

Dependencies are inferred from the claim text.