Methods to Treat Diseases with Protein, Peptide and Antigen Modification
AssigneeTianxin Wang
InventorTianxin Wang
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Abstract
This disclosure provides methods to modify protein and peptide and antigen to treat disease such as pathogen infection, autoimmune diseases and cancer. The method involves increasing the molecular weight of the protein by connecting multiple peptide units with site specific conjugation to extend the in vivo half life. This disclosure also provides methods to construct activatable enzyme, which becomes active when they reach the treatment target, therefore provide higher specificity for treatment.
Claims9
A method to extend the peptide half life in vivo, comprising:
- connecting at least 3 peptide monomers with a linker in a linear form to form an oligomer with the total molecular weight great than 60,000, wherein the linker is self immolative linker that is cleavable in vivo.
A conjugate to treat autoimmune disease comprising an auto antigen causing autoimmune disease and a second antigen having endogenous antibody in vivo, wherein the autoimmune disease is systemic lupus erythematosus.
Dependencies are inferred from the claim text.