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AssigneeThe Trustees of the University of Pennsylvania
InventorsJon LINDSTROM, Jie LUO
Estimating the term…
In one embodiment a vaccine composition comprises two or three AChR subunit constructs and an adjuvant. In some embodiments the AChR subunit construct is an AChR α1 subunit construct, an AChR β1 subunit construct, an AChR γ subunit construct, an AChR δ subunit construct, or an AChR ε subunit construct. In another embodiment, the invention provides a method of treating myasthenia gravis in a patient in need thereof, comprising administering a vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of AChR α1 subunit, AChR β1 subunit, AChR γ subunit, AChR δ subunit, AChR ε subunit, a fragment thereof, and a combination thereof, and an adjuvant.
A vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of AChR α1 subunit, AChR β1 subunit, AChR γ subunit, AChR δ subunit, AChR ε subunit, and fragments thereof;
A method of treating myasthenia gravis in a patient in need thereof, comprising administering a vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of AChR α1 subunit, AChR β1 subunit, AChR γ subunit, AChR δ subunit, AChR ε subunit, and fragments thereof, and an adjuvant.
A method of treating or preventing the onset of chronic myasthenia gravis in a patient, comprising administering a vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of an AChR α1 subunit construct, an AChR β1 subunit construct, an AChR γ subunit construct, an AChR δ subunit construct, an AChR ε subunit construct, and fragments thereof, and an adjuvant.
(canceled)
A method of preparing a vaccine composition comprising expressing one or more acetylcholine receptor subunit constructs in bacteria;
A method of treatment comprising administering to the subject one or more cytoplasmic domains of a transmembrane domain protein, wherein the cytoplasmic domain of the transmembrane domain protein is the object of an antibody-mediated autoimmune response.
Dependencies are inferred from the claim text.