C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficiency
AssigneeShire ViroPharma Incorporated
InventorsStephen Ruddy, Mark Cornell Manning, Ryan Erik Holcomb
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Abstract
Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficienty are disclosed.
Claims9
1-15. (canceled)
A lyophilized pharmaceutical composition comprising C1 esterase inhibitor, sodium citrate, at least about 2000 U C1 esterase inhibitor and less than about 5000 U C1 esterase inhibitor wherein when said lyophilized composition is reconstituted in sterile water to prepare a solution with a concentration of 400-600 U/mL of C1-esterase inhibitor the solution is suitable for subcutaneous administration to treat HAE, the sodium citrate has concentration of at least 10 mM, and the solution has a pH ranging from 6.5-8.0, and wherein the C1 esterase inhibitor comprises the amino acid sequence of residues 23 to 500 of SEQ ID NO:
- 1.
A lyophilized pharmaceutical composition comprising C1 esterase inhibitor, sodium citrate, at least about 2000 U C1 esterase inhibitor and less than about 5000 U C1 esterase inhibitor wherein when said lyophilized composition is reconstituted in sterile water to prepare a solution with a concentration of 500 U/mL of C1-esterase inhibitor the solution is suitable for subcutaneous administration to treat HAE, the sodium citrate has concentration of at least 10 mM, and the solution has a pH ranging from 6.5-8.0, and wherein the C1 esterase inhibitor comprises the amino acid sequence of residues 23 to 500 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.