Glycopeptide compositions
AssigneeXellia Pharmaceuticals Aps
InventorsIVONA JASPRICA, SABINA KESER, KATARINA PINDRIC
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Abstract
Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
Claims143
A composition comprising a glycopeptide antibiotic and an excipient selected from N-acetyl-D-Alanine or N-acetyl-Glycine for use as a medicament.
A pharmaceutical composition comprising a glycopeptide antibiotic;
- and an excipient selected from N-acetyl-D-Alanine or N-acetyl-Glycine.
A method for treating bacterial infections in a subject by administering an aqueous pharmaceutical composition comprising a glycopeptide antibiotic and an excipient selected from N-acetyl-D-Alanine or N-acetyl-Glycine.
A method for stabilizing a glycopeptide antibiotic in a pharmaceutical solution by mixing N-acetyl-D-Alanine or N-acetyl Glycine and the glycopeptide antibiotic.
Use of an excipient selected from N-acetyl-D-Alanine or N-acetyl-Glycine for stabilizing a pharmaceutical solution comprising a glycopeptide antibiotic.
A method of manufacturing a stable aqueous Vancomycin pharmaceutical solution comprising the steps of mixing a glycopeptide antibiotic and an excipient selected from N-acetyl-D-Alanine or N-acetyl-Glycine.
Dependencies are inferred from the claim text.