Oncolytic hsv1 vectors and methods of using the same
AssigneesThe Brigham and Women's Hospital, Inc., Ohio State Innovation Foundation
InventorsHiroshi Nakashima, Ennio Antonio Chiocca
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Abstract
Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic viruses described herein are suitable for treatment of several types of cancer, including glioblastoma.
Claims9
A method of killing intracranial tumor cells in a subject, comprising introducing into the vicinity of the tumor cells an oncolytic expression vector, said oncolytic expression vector comprising a nucleic acid comprising a nucleotide sequence encoding GADD34, or a biologically active portion thereof, wherein said nucleotide sequence is operably linked to an expression control sequence.
Dependencies are inferred from the claim text.