Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
AssigneeSynlogic, Inc.
InventorsDean Falb, Jonathan W. Kotula, Vincent M. Isabella, Paul F. Miller, Suman Machinani, Saurabh Saha, Adam B. Fisher, Yves Millet, Ning Li
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Abstract
Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
Claims63
A genetically engineered non-pathogenic microorganism for intratumoral administration comprising gene sequence(s) for producing one or more anti-cancer molecule(s), wherein the gene sequence(s) is operably linked to an inducible promoter and wherein the anti-cancer molecule is an immune modulator.
The genetically engineered bacterium of any one of claims 2-19, wherein the inducible promoter is induced by the hypoxic environment of a tumor.
Dependencies are inferred from the claim text.