Cdc-derived exosomes for treatment of ventricular tachyarrythmias
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Eugenio Cingolani, James Dawkins
Life of this patent
Estimating the term…
Abstract
Described herein are compositions and methods related to use of exosomes, including cardiosphere derived cell (CDC)-derived exosomes for treatment and prevention of heart related disease and conditions, such as ventral arrhythmias, such as tachycardias. CDC-derived exosomes delivered by endocardial injection can diminish the total amount of isolated late potentials associated with an isthmus of slow conduction, while reducing the isoelectric interval between late abnormal ventricular activity and decreasing the incidence of inducible ventricular arrhythmias, thereby providing a biological treatment for arrhythmias which otherwise requires therapeutic interventions with adverse effects.
Claims21
A method of treating a cardiac arrhythmia, comprising:
- administering a therapeutically effective amount of a composition comprising extracellular vesicles to a subject afflicted with a cardiac arrhythmia, thereby treating the subject.
A method of improving cardiac performance in a subject, comprising:
- administering a composition comprising extracellular vesicles to a subject.
A method of preventing arrhythmias in a subject comprising:
- administering a composition comprising extracellular vesicles to a subject.
Dependencies are inferred from the claim text.