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US 2019/0160077 A1Published application
Transdermal pharmaceutical compositions comprising active agents
AssigneeBesins Healthcare Luxembourg Sarl
InventorsValerie MASINI-ETEVE, Denis CANET
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Abstract
The present invention provides compositions and methods for providing sustained release of an active agent through the skin of a subject, wherein a pharmaceutical percutaneous composition comprises at least one fatty acid ester and a therapeutically effective amount of active agent.
Claims12
1-22. (canceled)
A sustained release pharmaceutical composition for topical administration of dihydrotestosterone (DHT) to a skin surface comprising:
- at least 0.01% by weight of the total weight of the pharmaceutical composition of DHT;
- 0.01% to 5% by weight of the total weight of the pharmaceutical composition of a fatty acid ester;
- water;
- a C2-C6 monoalcohol;
- a fatty acid;
- and
- 0.05% to 5% by weight of a gelling agent,
- wherein the weight:weight ratio of the fatty acid ester in the composition to the DHT in the composition is at least 4:1 fatty acid ester:active agent.
5 more elements
Dependencies are inferred from the claim text.