Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
AssigneeWex Medical Limited
InventorsHelmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
Life of this patent
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Abstract
The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
Claims17
1-28. (canceled)
A method for the treatment of peripheral neuropathy, neuropathic pain, allodynia or hyperalgesia, which has developed as a consequence of chemotherapy comprising:
- administering one or more of tetrodotoxin, an analog, derivative, or pharmaceutically acceptable salt thereof, to a subject suffering from peripheral neuropathy, neuropathic pain, allodynia, or hyperalgesia which has developed as a consequence of chemotherapy.
The method of 36, wherein each dose is in an amount of between 5 μg and 2000 μg.
A method for the treatment of peripheral neuropathy, neuropathic pain, allodynia or hyperalgesia, which has developed as a consequence of chemotherapy comprising:
- subcutaneously administering a unit dose in the range of 5 μg to 500 μg of one or more of tetrodotoxin, an analog, derivative, or pharmaceutically acceptable salt thereof, to a subject suffering from peripheral neuropathy, neuropathic pain, allodynia, or hyperalgesia which has developed as a consequence of chemotherapy.
Dependencies are inferred from the claim text.