Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
AssigneeUniversity of Maryland, Baltimore County
InventorKATHERINE L. RADTKE
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Abstract
The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
Claims12
A method of inducing apoptosis and/or inhibiting the growth of cancer cells, the method comprising administering to a subject in need of such treatment a therapeutically effective amount of a prodrug of a halogenated pyrrolopyrimidine or thienopyrimidine compound having the following formula:
- wherein X is S or NH and Y is H, Br or I.
A method of inducing apoptosis and/or inhibiting the growth of cancer cells, the method comprising administering to a subject in need of such treatment a therapeutically effective amount of a prodrug of a halogenated pyrrolopyrimidine compound or halogenated thienopyrimidine compound having the following formula:
- wherein R1 and R2 are selected from
- R1=BOM, R2═I;
- R1=Tos, R2═I;
- and
- R1 is selected from the group of protective groups consisting of:
- R2 is H, Br or I,
- wherein BOM is benzyloxymethyl and Tos is p-toluenesulfonyl group.
A method of inhibiting cancer proliferation activity and the use thereof for cancer treatment in an individual, the methods involving administering to the individual a prodrug having the following structure;
- that is converted in the individual to the following compound
Dependencies are inferred from the claim text.