Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Q is monocyclic heteroaryl substituted with one to three Ra;
• R2, R3, and R4 are independently selected from hydrogen, halo, and ORd;
• Y is CH2;
• X is O or CH2;
• R5 is halo, OH, CHO, or OCH3;
• R6 and R7 together form oxo;
• each Ra is heteroaryl substituted one to three Rc;
• each Rc is independently selected from the group consisting C1-8alkyl and haloC1-8alkyl;
• Rd is hydrogen, C1-8 alkyl, haloC1-8 alkyl, C2-8 alkenyl, haloC2-8 alkenyl, C2-8 alkynyl, and haloC2-8 alkynyl.