New treatment for the non alcoholic steatohepatitis and fibrosis

Method for the prevention or treatment, preferably treatment, of NASH comprising the administration to a person in need thereof of a therapeutically effective amount of a compound of formula (I)

• wherein
• R1 represents:
• a group —C(O)CR4R5CR6R7C(O)OH;
• a group —C(OH)(H)CR4R5CR6R7C(O)OH;
• a group
• or
• a —(CH2)4C(O)OH group;
• m represents an integer ranging from 0 to 8;
• R2 represents:
• a C6 to C10 aryl group optionally substituted;
• or
• a 5 to 10-membered heteroaryl group optionally substituted;
• R3, identical or different, represent:
• an alkyl, linear or branched, C1 to C5, preferably C1 to C4;
• for example methyl, ethyl, propyl, isopropyl, butyl, tert-butyl;
• optionally substituted by a carbocycle group or by a heterocycle group, the carbocycle being in 5 to 10 members, saturated, partially unsaturated or aromatic, substituted or non-substituted, the heterocycle comprising 5 to 10 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and which may comprise 1, 2 or 3 heteroatoms, identical or different, in particular chosen from nitrogen, oxygen or sulphur,
• R4, R5, R6 et R7, identical or different, represent:
• a hydrogen atom;
• an alkyl group, linear or branched, in C1 to C5, preferably C1 to C4;
• a 5, 6 or 7-membered carbocycle group saturated, partially insaturated or aromatic, non-substituted or substituted;
• or
• R4 and R5 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted, preferably saturated;
• for example cyclopentyl or cyclohexyl;
• or
• R6 et R7 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted, preferably saturated;
• for example cyclopentyl or cyclohexyl;
• or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.