Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
AssigneesLumosa Therapeutics Co., Ltd., Shanghai Lumosa Therapeutics Co., Ltd.
InventorsChan-Jung LI, David Chih-Kuang Chou, Jin-Ding Huang, Shin-Jr Tsai, Shu-Wen Kuo, Yu-En Tien
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Abstract
The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
Claims15
1-40. (canceled)
A pharmaceutical formulation comprising sebacoyl dinalbuphine ester (SDE) and a release-controlling solution, wherein the formulation is suitable for administration by injection and releases the nalbuphine ester prodrug in an extended manner.
Dependencies are inferred from the claim text.