US 2019/0160044 A1 · TOPICAL PREPARATION FOR SKIN TISSUE PROTECTION AND REPARATION

Abstract

The present invention relates to a topical preparation for skin tissue protection and reparation. The complex preparation includes the following components: (1) polyethylene glycol; (2) water; and (3) flavonoid compound. The complex preparation may: (1) repair skin injury or promote wound healing; (2) eliminate scars; (3) prevent or treat skin injury caused by radiotherapy; and (4) prevent or treat radiodermatitis.

Claims18

Dependent claims

A complex preparation for skin protection and reparation, comprising the following ingredients:

(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound.

1 more element

A preparation method of a complex preparation for skin protection and reparation, the method comprising the steps of:

step (1) heating the polyethylene glycol to 55° C.-90° C. to obtain a polyethylene glycol solution;
step (2) dissolving the flavonoid compound in the polyethylene glycol solution;
step (3) adding water to the polyethylene glycol solution to be a mixed solution, or first dissolving the salt/allantoin in the water, then adding the salt/allantoin solution to the polyethylene glycol, and after mixing the mixed solution uniformly, cooling the mixed solution to normal temperature to be a solution system;
wherein
the complex preparation comprises the following ingredients:
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5.

137 more elements

A product for skin protection and reparation obtained by using a complex preparation, wherein

the product is a health care product/a cosmetic product/a medicine;
the product is prepared with the complex preparation for skin protection and reparation and adjuvants, excipients, flavoring agents or combinations of the adjuvants, excipients, and flavoring agents;
and
the medicine is:
(1) a medicine for preventing or treating radiodermatitis;
or
(2) a medicine for treating and preventing skin injury caused by radiation therapy;
wherein
the complex preparation comprises the following ingredients:
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5.

141 more elements

Dependencies are inferred from the claim text.

Abstract

Claims18

Dependent claims

A complex preparation for skin protection and reparation, comprising the following ingredients:

(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound.

1 more element

A preparation method of a complex preparation for skin protection and reparation, the method comprising the steps of:

step (1) heating the polyethylene glycol to 55° C.-90° C. to obtain a polyethylene glycol solution;
step (2) dissolving the flavonoid compound in the polyethylene glycol solution;
step (3) adding water to the polyethylene glycol solution to be a mixed solution, or first dissolving the salt/allantoin in the water, then adding the salt/allantoin solution to the polyethylene glycol, and after mixing the mixed solution uniformly, cooling the mixed solution to normal temperature to be a solution system;
wherein
the complex preparation comprises the following ingredients:
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5.

137 more elements

A product for skin protection and reparation obtained by using a complex preparation, wherein

the product is a health care product/a cosmetic product/a medicine;
the product is prepared with the complex preparation for skin protection and reparation and adjuvants, excipients, flavoring agents or combinations of the adjuvants, excipients, and flavoring agents;
and
the medicine is:
(1) a medicine for preventing or treating radiodermatitis;
or
(2) a medicine for treating and preventing skin injury caused by radiation therapy;
wherein
the complex preparation comprises the following ingredients:
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
and the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10;
or
(1) polyethylene glycol;
(2) water;
and
(3) flavonoid compound;
(4) soluble salt;
and/or
(5) allantoin;
wherein the polyethylene glycol is a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000;
the flavonoid compound is selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, apigenin and any combination of two or three thereof;
the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts;
and in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound, the salt and the allantoin is 50-80 to 20-30 to 2-10 to 0.2-2 to 1-5.

141 more elements

Dependencies are inferred from the claim text.

Topical preparation for skin tissue protection and reparation

Life of this patent

Abstract

Claims18

Topical preparation for skin tissue protection and reparation

Life of this patent

Abstract

Claims18